Shelly Morrison played the voice of Mrs. Portillo. At first, I didn't recognize her as a Latina due to her non-Latina like last name; yet, it turns out Shelly Morrison is her acting name. Her birth name is Rachel Mitrani. She was born in 1936 in New York. Spanish being her native language, Morrison mainly represented ethnic roles or Latina characters. Morrison's career seemed to be heavily limited, even more so than Alazraqui. For example, in Shark's Tale, she played Mrs. Sanchez. Her most recent work besides Handy Manny was My name is Earl as Maria in 2006.
Except for Alazraqui, Morrison and Valderrama other characters from Handy Manny are played by non-Latino/as, mainly White Americans. For instance, the voice of Kelly is played by Nancy Truman. Tom Kenny lent his voice for Mr. Lopart. He is eminent for his role, the Sponge Bob Squarepants.